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You might want to read an introductory chemistry textbook. Here's the amazon page for the newest edition of the chemistry book I used. While many people don't like textbook reading, it is often times better than trying to learn things from online resources as it presented in an organized fashion to help you develop conceptual understanding of the topics. You don't need to buy the books necessarily (although that will support the authors!), there are places online where you can find books, like popular bays.

After developing a good conceptual understanding of ordinary chemistry, you should try an organic chemistry book, which will help in understanding (semi)systematic names, like 4-HO-DMT (although "tryptamine" isn't a systematic name). Systematic names are used because there are basically a limitless number of carbon compounds (aka organic compounds) which can be synthesized, so naming them with a system of rules makes it easier to share with other chemists (or those who understand systematic naming).

tldr textbooks

Aw, shucks. Thanks for the early morning ego boost.

Also, I just want to thank you for never giving up on the search for knowledge even in the face of intimidation. It's being able to help knowledge thirsty people like you that makes people like me happy to contribute. The more educated everybody is the better off the world is and I commend you for trying to attain as much knowledge as you can and not be afraid to ask for help along the way. At first you may get intimidated by a lot of this stuff but after asking enough people for explanations of it, it will act almost as a rosetta stone and you'll be able to decipher it much more easily.

Oh and books like this might also help you to understand some of the terminology a lot better: http://www.amazon.com/Handbook-Clinical-Psychopharmacology-Therapists-Preston/dp/1608826643

I haven't personally done DMT, I have only tripped on mushrooms and LSD, but my friend has experienced the same breakthrough DMT trip you described and said that after a certain point, your brain is so overloaded with sensory information that you reach a point which is called (as he described it) "The Ineffable". You are virtually unable to describe anything that is going on, you are constantly changing between intense emotional feeling, insane visuals, and profound and possibly life changing epiphany-like thoughts. While on shrooms and acid I frequently see fractals and amazing swooping mosaic patterns, and get the insane philosophic thoughts. Virtually every time I have done a hallucinogen it has changed some aspect of my life, I think it was my 3rd or so mushroom trip that was the most drastic. Anyway, there is a very interesting book on this sort of stuff that pays special attention to mushrooms called Food of The Gods by Terence Mckenna (psychonaut) and goes in depth to try to explain why humans crave these experiences of overwhelming ecstasy and how it has shaped our evolution over the span of time.

despite people telling you this cant be done this can easily be done with the enzyme trypsin . trypsin cleaves lysine amino acids. you can buy this pure from amazon .


enzymes are like little robots from the movie wall-e. they continue to do a job until it is done or they are denatured/inhibited. this means that you could use a any amount to get the job done but the less you use the longer it will take.

Trypsin is the ideal enzyme because it will cleave lysine and optimal pH is that of tap water.

IMO this is the best option due to your limited chemistry knowledge.

preheat a thermos to about 40C take a small quantity of about 100-200 mg of enzyme and the contents inside one vyvanse pill. place them contents in the thermos and seal the thermos with lid for about 2 hours ( it doesnt matter if it is longer, you can do it over night if you wish). now, heat the contents until boiling, this will denature the enzyme which is critical because you dont want to mess with enzymes and the stomach (ie ulcers). cool, consume, and enjoy.

Coursera.org has a course available currently taught by UPenn called Fundamentals of Pharmacology. That may be a fun way to learn. Additionally you could order a (smaller) pharmacology textbook. However if you're into theory and mathematically describing receptor pharmacology (meticulously) then anything by Terry Kenakin would be right up your alley.

I learned from using resources available to me starting in high school with the internet (wikipedia, erowid) and the molecular mechanisms of these drugs and receptors interested me. I usually recommend this book to the interested layman as well due to its brevity and conciseness.

Otherwise, I would look around all the open courseware sites (harvard, yale, mit, caltech all offer free courses.) If you are going to college, major in biochemistry or another foundational science, not a specific subdiscipline like neuroscience or pharm directly from undergrad. (my advice particularly)

Ok this seems like a winner for anyone else interested


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I would definitely start with a Med Chem textbook. I've not read the one that u/fourninetwo posted but I use Foye's Principles of Medicinal Chemistry pretty frequently (which is also on TPB) and think its pretty good. Or an amazon link

As a pure reference encyclopedia Rang and Dales pharmacology is an excellent resource. All information is presented clearly and has brilliant diagrams and tables which explains concepts well. It is a little large and heavy to carry around though.

I am currently reading Toxicology: Principles and Methods by M A Subramanian and I find it very well presented and concise, also fits in a bag easily and isn't too heavy so is practical to carry around.

Fundamentally, a drug receptor is a molecule that is meant to receive chemical "signals" from outside sources. These chemicals bind to the receptor, causing some change that triggers the effect of the drug. This change is often electric in nature.

As far as artificial receptors go, I've only heard of them being used for testing purposes, like this synthetic receptor used to detect all drugs in the methamphetamine family.

As for your example with a housefly, I've never heard of an artificial receptor being grafted to a living creature, but that is something I'd be interested to hear about if anyone has heard of such an experiment.

If you'd like some reading in that subject and you have some background in biology/biochemistry, this text is a great resource.

Well talking about the good Doctor, always fun the NYTs Magazine piece, and the movie, enjoy. :-)


https://www.nytimes.com/2005/01/30/magazine/dr-ecstasy.html


https://www.amazon.com/Dirty-Pictures-Alexander-Shulgin/dp/B005JZBPNW

If anyone is looking for a book that will actually change your view on psychedelics, I highly recommend The Chemistry of Mind-Altering Drugs by Daniel Perrine. Although it is literally a textbook, it's written like a story as the author himself acknowledges that drugs are not just chemical structures but have important cultural context. Here's an Amazon link for a used copy. It really did shift my perception of a lot of different things. I'm a chemistry student so it was probably particularly impactful but there's a great appendix in the back that goes over the basics of organic chemistry so you can really make yourself understand if you spend the time.

Have you ever seen the [The Encyclopedia of Psychoactive Plants] (http://www.amazon.com/dp/0892819782/ref=cm_sw_r_an_am_ap_am_us?ie=UTF8) by Christian Rätsch (published in 2005)? It's very comprehensive including a lot of information on cultural context for basically all the known psychoactive plants on the planet (at the time of publication at least). My copy at home has like hundreds of sticky notes in it, haha. I definitely recommend that book.

> Interesting, thank you for telling me. This is what I tried.
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> https://www.amazon.com/Doctors-Best-Strength-Enteric-30-Count/dp/B0011FTJZ0

It's like comparing ALA to RLA. RLA is far superior. Or L-Theanine with DL-Theanine.

Hmm they don't say. It's an important question before buying any brand of SAMe.

I read Drugs and Behavior: An Introduction to Behavioral Pharmacology 6th ed. for a Drugs and Behavior course. Great for an introduction.

For psychology I'd have to recommend Biopsychology. Had to read this one for Brain and Behavior.

I'll throw The Lucifer Princple in just because I love it.

I have always found it interesting that they created a special word for withdrawal in the antidepressant world. Of the handful of drugs from which I've experienced withdrawal (opiates, benzo's, anti-D's) SSRI's were definitely the the most bizarre/terrifying. Brain zaps, tremors, dreams as if from someone else's consciousness, restless legs/ankles/elbows, hollow/emptiness that led to suicidal indifference. <Shudder> Elated to have found other solutions for my anxiety and depression, personally(!)

It's nice to see they are actually studying this as well as using the word 'withdrawal' within the study.



As for how effective SSRI's actually are, this may be an interesting read for those interested in such research and analysis of the pharmaceutical industry: http://www.amazon.com/The-Myth-Chemical-Cure-Psychiatric/dp/0230574327 It's a hard science read with +/- 50 pages of footnoted research, including that of studies suppressed by the pharmaceutical industry.


That said, one would hope SSRI's are effective for certain types of depression and anxiety disorders, brain receptor configurations, etc. For me personally, there was a time where one in particular seemed to be helping but upon reflection later/after, it felt more like a chunk of my emotional being had been sliced out of my psyche/consciousness with a scalpel.. like a knife to a slab of meat. It no longer felt like a grenade was going to explode at any moment within the center of my chest, but with it came a numbness that was actually worse in hindsight..



Apologies for going a bit OT, OP.

If you genuinely want something to look up specific information, then getting a textbook (even as a PDF) may be your best bet as a one stop shop for medications. Something like Rang and Dale's is pretty standard amongst medical and pharmacy students for example.

> Care to share?

This would be a good place to start:

https://blogs.bmj.com/bmjebmspotlight/2018/09/16/cochrane-a-sinking-ship/

https://www.amazon.com/Deadly-Psychiatry-Organised-Denial-Gotzsche-ebook/dp/B014SO7GHS/ref=sr_1_4?s=books&ie=UTF8&qid=1542263774&sr=1-4

https://www.amazon.com/Deadly-Medicines-Organised-Crime-Healthcare/dp/1846198844

Interesting, thank you for telling me. This is what I tried.

https://www.amazon.com/Doctors-Best-Strength-Enteric-30-Count/dp/B0011FTJZ0