Best products from r/longevity

I'm not sure if this qualifies for what you're looking for, but I'll re-post my highlights from a few weeks ago in case it helps:

• Exercise. “In SPARK, John J. Ratey, M.D., embarks upon a fascinating and entertaining journey through the mind-body connection, presenting startling research to prove that exercise is truly our best defense against everything from depression to ADD to addiction to aggression to menopause to Alzheimer's. Filled with amazing case studies (such as the revolutionary fitness program in Naperville, Illinois, which has put this school district of 19,000 kids first in the world of science test scores), SPARK is the first book to explore comprehensively the connection between exercise and the brain. It will change forever the way you think about your morning run---or, for that matter, simply the way you think“. Source: https://www.amazon.com/Spark-Revolutionary-Science-Exercise-Brain/dp/0316113514/ref=sr_1_1?s=books&ie=UTF8&qid=1522973939&sr=1-1&keywords=Spark%2C+The+Revolutionary+New+Science+of+Exercise+and+the+Brain
  
• Eat a healthy diet and follow some of the practices taken from Blue Zones, which are populations that have an unusually high number of centenarians. Some key take-aways from studies blue zones (Source: https://www.amazon.com/product-reviews/1426216556/ref=cm_cr_dp_d_cmps_btm?ie=UTF8&reviewerType=all_reviews):
  
  • Long-lived people live on a high-carb, low-fat, plant-based diet;
    
  • Long-lived people eat a lot of vegetables, including greens;
    
  • Whenever they can get it, long-lived populations eat a lot of fruit;
    
  • When animal products are consumed, it’s occasionally and in small amounts only;
    
  • Long-lived people had periods in their life when a lot less food was available and they had to survive on a very sparse, limited diet;
    
  • Long-lived people live in a sunny, warm climate;
    
  • Long-lived people consume beans in some form or another;
    
  • Nuts appear to be good for health;
    
  • The typical diet is very simple and many essentially eat the same simple foods every day
    
  • Quality food over variety is more important;
    
  • They had an active lifestyle and moved a lot
    
  • Many of them got 5 to 6 hours of moderate exercise per day;
    
  • Many of them loved to work and had a sense of purpose in life;
    
  • Many had large families;
    
  • None of them smoked or ate massive amounts of food.
    
• Be a super-ager – “Which activities, if any, will increase your chances of remaining mentally sharp into old age? We’re still studying this question, but our best answer at the moment is: work hard at something. Many labs have observed that these critical brain regions increase in activity when people perform difficult tasks, whether the effort is physical or mental. You can therefore help keep these regions thick and healthy through vigorous exercise and bouts of strenuous mental effort.” Source: http://www.nytimes.com/2016/12/31/opinion/sunday/how-to-become-a-superager.html
  
• Boost your microbiome by eating a diverse diet. “Diet is perhaps the biggest factor in shaping the composition of the microbiome,” he says. A study by University College Cork researchers published in Nature in 2012 followed 200 elderly people over the course of two years, as they transitioned into different environments such as nursing homes. The researchers found that their subjects’ health – frailty, cognition, and immune system – all correlated with their microbiome. From bacterial population alone, researchers could tell if a patient was a long-stay patient in a nursing home, or short-stay, or living in the general community. These changes were a direct reflection of their diet in these different environments. “A diverse diet gives you a diverse microbiome that gives you a better health outcome,” says Cryan. Source: http://www.bbc.com/future/story/20140221-can-gut-bugs-make-you-smarter
  
• Have a healthy mind-set – don't ever succumb to the stereotypical mind set that getting older = decline. “To Langer, this was evidence that the biomedical model of the day — that the mind and the body are on separate tracks — was wrongheaded. The belief was that “the only way to get sick is through the introduction of a pathogen, and the only way to get well is to get rid of it,” she said, when we met at her office in Cambridge in December. She came to think that what people needed to heal themselves was a psychological “prime” — something that triggered the body to take curative measures all by itself. Gathering the older men together in New Hampshire, for what she would later refer to as a counterclockwise study, would be a way to test this premise. The men in the experimental group were told not merely to reminisce about this earlier era, but to inhabit it — to “make a psychological attempt to be the person they were 22 years ago,” she told me. “We have good reason to believe that if you are successful at this,” Langer told the men, “you will feel as you did in 1959.” From the time they walked through the doors, they were treated as if they were younger. The men were told that they would have to take their belongings upstairs themselves, even if they had to do it one shirt at a time. At the end of their stay, the men were tested again. On several measures, they outperformed a control group that came earlier to the monastery but didn’t imagine themselves back into the skin of their younger selves, though they were encouraged to reminisce. They were suppler, showed greater manual dexterity and sat taller — just as Langer had guessed. Perhaps most improbable, their sight improved. Independent judges said they looked younger. The experimental subjects, Langer told me, had “put their mind in an earlier time,” and their bodies went along for the ride.” Source: https://www.nytimes.com/2014/10/26/magazine/what-if-age-is-nothing-but-a-mind-set.html
  
• Live a life that has meaning – or, in other words, have a personal mission statement in life. Strive to accomplish something or to help others. “It is the pursuit of meaning is what makes human beings uniquely human. By putting aside our selfish interests to serve someone or something larger than ourselves -- by devoting our lives to "giving" rather than "taking" -- we are not only expressing our fundamental humanity, but are also acknowledging that that there is more to the good life than the pursuit of simple happiness.” Source: https://www.theatlantic.com/health/archive/2013/01/theres-more-to-life-than-being-happy/266805/
  
• Volunteer and help others. “Volunteering probably reduces mortality by a year and a half or possibly up to two years for people who are in their senior years,” says Stephen G. Post, a professor of preventive medicine at Stony Brook University School of Medicine and the author of The Hidden Gifts of Helping and Why Good Things Happen to Good People. “If you could put the benefits of helping others into a bottle and sell it, you could be a millionaire in a minute.” Source: https://www.thefreelibrary.com/Why+do+we+hesitate+to+help%3F-a0352848707
  
• Do strength training – there is an association between muscular strength and mortality in men (2008). Source: https://www.bmj.com/content/2/4225/927.4
  
• This is also a great book: 'How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease' by Michael Greger: https://www.goodreads.com/book/show/25663961-how-not-to-die . You can find a summary of it here: https://www.allencheng.com/how-not-to-die-by-michael-greger-summary/

Hi there, this comment is overdue but severely needed, my apologies for the delay my stat mech exams interrupted my happy redditing. This post replies more in depth than my previous one which admittedly was too short to reply fully to the others.

The Mediterranean diet

In response to the third message “It’s the Mayo Clinic, bud, the Mayo Clinic” regarding the health aspects of the traditional Mediterraean diet being a plant based diet, we can look at the link provided and see that this it is clearly not a plant based diet. According to the presented pyramid therein, assuming that it is accurate, we see that the Mediterranean traditional diet consists of 4 parts animal products and 6 parts plant products. To designate this as “plant based” is like saying the United States is a liberal nation. It completely disregards basically half the thing. Actual plant based diets such as vegetarian, vegan and traditional Okinawan diets consist of upwards of 90% plants. Incidentally all of this does support the original point I was trying to voice, namely that the more plants people eat, the healthier they get. Since the Mediterranean diet contains more plants than the Standard American Diet, and it has an equivalent (and probably slightly better) healthcare system, the expected result would be high life expectancies. It just doesn't go far not enough to get more than Andorran level life expectancies.

"Acclimatized phenotypes", Inuit & Maasaai

The main argument mentioned against the plant based position involves the claim that two major metabolic phenotypes exist due to acclimatization to hot and cold climates, neatly summarized as "monkeys don't eat salmon and Inuits don't eat bananas". Despite the 'catchiness' of that phrase, it turns out to be wrong. Orang-utans for example do eat fish. They are known to furnish spears and hunt for all kinds of fish in the Borneo rainforests (what is left of them anyway). And while the Inuit may not traditionally eat bananas this does not mean that they wouldn't if they could. And that if they did it wouldn't mean a measurable improvement of their health. Banana's just happen to be very expensive to bring all the way to some remote village by motor sled. So getting such an addition to the diet is just difficult not necessarily useless or genetically harmful. The idea that Inuit are fine regardless of their intake of animal products is seriously questionable. The same goes for the Maasaai.

Furthermore if the acclimatization hypothesis purported by hastasiempre is correct we can cure all cardiovascular disease, diet related cancers, Alzheimer's disease and a great number more, simply by changing the thermostat.

In addition to these two points the story presented in the three posts above is inconsistent. The Chinese traditional diet is included in the “heat acclimated phenotype” which is especially odd since Beijing regularly looks like this. China does contain some extreme regions like Hainan Island and the disputed islands in the South China Sea which are tropical but the region where the vast majority of the population lives is as temperate as Northern Europe. The climate of the northern part of the Yellow River valley is comparable with the climates of southern parts of Sweden, Poland and Lithuania, albeit with higher concentrations of rainfall in the summer. And Southern China mostly has a temperate climate equal to the climate of Serbia or the Russian Black Sea shores.

Finally, and this is why I referenced to Dawkins earlier, even if a careful rational evaluation of the available were to indicate differences in cholesterol and animal protein adaptation this would not occur due to acclimatization but due to evolutionary change in the genome. Acclimatization is not a way to get major changes in the body such as the ones in question here. This is because acclimatization, as far as it is long term and goes beyond mere direct physiological reactions like shivering, relies on changes in gene expression (activation). You can't express genes for eating additional cholesterol from ones diet if those genes do not exist. Consequently the evolutionary history of an organism is vastly more important than the acclimatization of it to its surroundings during its life time (this is one of the cornerstones of Darwinism and one of the main reasons why Lamarckism was eventually discarded).

Though I do go into a bit more detail below the general gist of this essay can be summarized by this source which also provides ample references to the medical literature.

5 out of 7 figure

>you are right that the prevalent traditional diets are plant-based, maybe around 5 out of the 7 Bil people eat diets which are mainly carbs

While it is nice to hear someone say “you are right”, in this case I’d rather you didn’t because the 5 out of 7 figure you are giving is, as far as I can tell, not true. The figure (which I have been unable to find in any literature so far, which adds to my doubts about it) I must assume refers to plant vs animal based diets. In populations where over the course of evolutionary history (the last 2 million years in very broad terms, the last 100,000 years in general terms after the migration out of Africa and the last 10,000 years in particular since the invention of agriculture and animal husbandry) animal products have outweighed plant based ones adaptation to meat eating for example could have occurred. Based on the current pastoralist population of the planet however, see this rough estimate I made, pastoral societies form approximately 2% of the world’s population. And this tally includes groups such as the Fula of western Africa of which only a third is pastoral, therefore likely overestimating the total pastoral population. In this small pastoral population it may very well be that genetic mutations have occurred that would allow its members to consume any level of animal based products without negative consequences. The Maasaai could be such a group, although the Inuit are not. However, more importantly most of the world's population does not belong to this category. Consequently there is no way to get a animal product adapted phenotype in the human species based on our evolutionary history (genetic engineering would be a whole different case of course, but so far people balk at such practices because they consider them unethical).

This estimate is probably to high even as most of the pastoral population does not belong to the adaptation capable group and the Maasaai are probably more exception than rule here. For example the Fula and the Inuit are not capable of regulating the LDL and HDL cholesterol levels to optimum ranges regardless of intake as the Maasaai are. Because of this they either suffer similar levels of cardiovascular dissease (Inuit) or have to resort to energy intake restriction and high levels of activity (Maasaai). The fact that some pastoralists do not have this adaptation is explained by this general reference, the fact that pastoralist societies are often cut of from one another by agricultural societies, and finally the fact that mutations such as those didn’t tend to spread through agricultural societies because they exact energy costs on populations that don’t use them. This of course does mean that Maasaai genes do have an evolutionary advantage in modern day North America but there is clearly not enough genetic transfer nor generational overturn for the mutation to spread through the North American population at this time. A little later on in the longer post the Tuoli people are also mentioned as having a similar condition as the Maasaai, literally the first hit on google however states that the evidence on them should be taken with “a whoppin’ huge grain of salt” and that it should not be used for quoting to the benefit of meat nor citing it as evidence, because the Tuoli were feasting the day the researchers of the China Study came. Thus they seemed to consume a lot of meat yet they had the health of plant eaters (which they really were the rest of the year).

Conclusion

>there is NO single HEALTHY diet

Yes there is, a plant based one, that is at least 90% or ideally more, of energy intake from a wide variety of non-toxic plants, while ensuring either via micro intake of animal products or supplements that B12 and Omega-3 intake stays sufficient. Ample evidence in favour of this assertion has been posted in this thread for anyone to verify this statement, but also here, here, here and here.

Cheerio, :) !

Interview with hugely successful investor Jim Mellon at the Undoing Aging conference in Berlin 2019!

We cover reasons why it's a good time to invest in Anti-Aging and rejuvenation biotechnology today, the ethical reasons why we should, and effective advocacy: i.e. what one would say to a billionaire to convince them that investing in longevity medicine is a good thing to do now.

Jim raised over $150 Million for his venture Juvenescence recently!

Bio: Jim Mellon is an investor with an interest in several industries. After studying PPE at Oxford, Jim worked in Asia and in the US for two fund management companies, GT Management and Thornton & Co, before establishing his own business in 1991. This business is now known by two names - Charlemagne Capital, recently acquired, and Regent Pacific Group, listed in Hong Kong. Jim's private investment company, The Burnbrae Group, is a substantial landlord in Germany and the Isle of Man, and owns the group Sleepwell Hotels. Jim is chairman and major shareholder of Manx Financial Group, Port Erin Biopharma Invesments and SalvaRx Group. He is also a director of Condor Gold, Fast Forward Innovations, Portage Biotech and West African Minerals Corporation, all publicly listed companies. Amongst his many successes, Jim is well known for notching up one of the AIM market's biggest successes with the sale of Uramin to Areva, the French nuclear giant.

Book 'Juvenescence: Investing in the age of longevity' - https://www.amazon.com/Juvenescence-Investing-longevity-Jim-Mellon-ebook/dp/B075WXX93Q

Wikipedia entry: https://en.wikipedia.org/wiki/Jim_Mellon

Medium piece: https://medium.com/neodotlife/juvenescence-jim-mellon-longevity-e9a415dd0569

Here’s a long discussion about making it at home: http://www.longecity.org/forum/topic/58153-how-about-producing-c60-at-home/



Most of these people use magnetic stirrers, but I couldn’t get it to move a liter of oil.



So this is what I do:



I use an ice-cream maker like this one:


https://www.amazon.com/Hamilton-Beach-68320-2-Quart-Capacity/dp/B001CGW338 (not that one specifically, but similar)




Because I assume the motor will overheat, I put it on a timer so it runs 15 minutes and is off 15 minutes.



I pour 1 liter of very high quality oil (or whatever amount you’re doing) into the bowl. Over the bowl, I crush 0.8 gram of fullerene powder between two stainless steel spoons. Generally the powder cakes to the spoons, so I “wash” the spoons in the oil until they are as clean as possible. By wash, I mean I rub the two spoons together in the oil and scrub off the caked on fullerene.


Into the bowl, I put the mixing paddle, and then I cover the bowl with cling wrap, making a single perforation to allow the mixing paddle to connect with the motor.



I put a black dish cloth over the top of the ice-cream maker and then let the timer stir it for 2 weeks. I keep it in a cool dark place during this time. When it’s done, there shouldn’t be any black sediment in the bottom. This is either a sign that it is not fully dissolved, or too much fullerene was added. I keep reading that not more than 0.9 grams will dissolve in a liter.



After two weeks, I filter it through a coffee filter into a dark glass bottle. I then wrap that bottle in a black dish cloth and store it in the refrigerator. Actually, first I set aside what I will use in a week so I don’t have to let the solution stand at room temperature to become liquid again. But I also keep that wrapped in a black dishcloth to avoid light.




Oh also, this Longecity forum has a ton of information. Useful also is getting the best quality oil, so maybe look to buy from a boutique producer: http://www.longecity.org/forum/forum/415-c60health/

So like you I learned about dr. Neil Riordan in January of 2018 and since then I have been researching mesenchymal stem cells to find out the truth of the matter oh, and guess what the stuff is real, this stuff is real and they really do heal the body and modulate the immune system, this stuff can literally heal a damaged heart after a heart attack or heal the brain after a stroke this stuff is going to change the world! You should read his book that he wrote about his work it'll blow your mind he's definitely not a fraud, https://www.amazon.com/Stem-Cell-Therapy-Disrupting-Transforming-ebook/dp/B071GRNQPX

also Mel Gibson isn't the only famous celebrity with millions of dollars going down to Panama for these cells

Lactobacillus reuteri strain ATCC PTA 6475 increases oxytocin and survives oral ingestion. It's naturally found commonly in breast milk but can get easily out competed by other bacteria in the digestive system since it isn't as aggressive at colonizing the gut. Just this year a probiotic with it was finally released. Looks like a potentially very useful supplement to consider.

https://examine.com/supplements/lactobacillus-reuteri/

https://www.amazon.com/BioGaia-Osfortis-Probiotic-Wellness-Contains/dp/B07T751F26/ref=sr_1_2?crid=1I80HZ991F8AF&keywords=biogaia+osfortis&qid=1567291889&s=gateway&sprefix=biogaia+o%2Caps%2C194&sr=8-2

The book you mention, Handbook of the Biology of Aging is probably the best I've run across for what you are looking for. It is very much like review articles. They cover the major research up to publication date (in 2015), and dive into specifics going over experimental design and methodologies.

A simpler, shorter, and more accessible intro for those who don't have your credentials is Biology of Aging. But if you wanted a very general sweep that is still focused on those with a biology education to supplement the deeper dive, this would be a good choice. (For example the Handbook of the Biology of Aging focuses on animal and human aging whereas the Biology of Aging has a section on plant senescence as well).

Laura Deming also has a good Longevity FAQ that covers the aging research landscape but more importantly for your needs contains links to papers and clinical trials at the bottom.

The best source is Natto.
You also need vitamin D3 to absorb the k2 fully

i found on Amazon a good source with K2 and D3 together.


I take mainly for the arteries.. I also tried the Natto. It is not as bad as it looks.

Yup - I have pre-diabetic levels and am debating if I should go on metformin early or not. PCP/endos don't recommend it. Chris Masterjohn even said that he thinks it's too major of a pathway to interrupt for that long of a time. Others like Peter Attia, however, are all about it.

I'm a bit torn, but given my known condition and genetics, it might be a good gamble for me.

BTW, masterjohn recommended these B vitamins as the only ones he likes:

https://www.amazon.com/Source-Naturals-Coenzymate-Complex-Tablets/dp/B000GFPD2Y/

Its not the cheapest thing in the world but I was doing this for a while when I had a well paying job and it was pretty great. The dose on the bottle is 2 caps for 1.5g EPa and I was taking 4 so getting 3g/day. No negative side effects. No fish burps. If you have the money Id say worth a try.

Nutrigold Triple Strength Omega-3 Fish Oil Supplement, 2100 mg, 180 Softgels
https://www.amazon.com/dp/B004O2I9JO

Molecular Biology of Aging. I own a copy and its a nice collection of seminal papers that acts as a great primer to learn about aging and longevity.

https://www.amazon.com/Molecular-Biology-SPRING-HARBOR-MONOGRAPH/dp/0879698241

Nicotinamide riboside has been proven to increase NAD+ levels and you can get it pretty easily. This is the one I take: https://www.amazon.com/gp/product/B01NCQD4GF/ref=oh_aui_detailpage_o00_s00?ie=UTF8&psc=1
A couple of relevant studies on it:
https://www.ncbi.nlm.nih.gov/pubmed/17482543
https://www.ncbi.nlm.nih.gov/pubmed/18052316

This is an excerpt from a new book by Josh Mitteldorf and Dorion Sagan:

Cracking the Aging Code: The New Science of Growing Old-And What It Means for Staying Young

I haven't read the book yet, but I've been following the author's blog for several years. He has a unique, and I think convincing, take on why aging has evolved. His blog is my best source of information about new developments in curing aging.

I'm tired of reading the same longevity articles rehashed, too, but I posted this because it deserves to be seen.

https://www.elysiumhealth.com/product-plan is between 40 USD and 50 USD per month (depending on whether one prepays the entire year) for 250mg NR daily + 50mg Pterostilbene daily.

vs.:

• https://www.amazon.com/TRU-NIAGEN-advanced-booster-capsules/dp/B01IMF8D26 is 40 USD per month for 250mg NR daily
  
• https://www.amazon.com/Pterostilbene-Capsules-Double-Wood-Supplements/dp/B076M84NHY is 18/2 = 9 USD per month for 100mg pterostilbene 100mg daily
  
  Everything is free shipping.
  
  --> so in terms of price https://www.elysiumhealth.com/product-plan + (if you wish to ingest more Pterostilbene) https://www.amazon.com/Pterostilbene-Capsules-Double-Wood-Supplements/dp/B076M84NHY is a bit cheaper if you prepay elysiumhealth 1 year.

AOR. It uses the same form in many of the clinical studies.

Best price offhand was amazon.

15 mg 90 capsules for $29.99.

https://www.amazon.com/Advanced-Orthomolecular-Research-AOR-Capsules/dp/B00457KVBM

It's reassuring to know that these tech billionaires really are afraid of death and that this is their motivation. This is because that motivation isn't likely to go away (until they cure death), and also because likely most tech billionaires will have the same fear and motivation to cure aging.

Has anybody read the book referred to in the article - Homo Deus? I wonder if the author's argument that Sergey Brin wont live to see aging conquered is a philosophical one (like John Gray's in 'The Immortality Commission') rather than scientific? https://www.amazon.com/Immortalization-Commission-Science-Strange-Quest/dp/0374533237

Well, Brin is 43 so 2 years younger than me. I believe the life expectancy of an average 43 y.o. American male right now is close to 80 or (37 more years of life). Given his wealth, his clear motivation to live as long as possible, and his access to the latest knowledge and science as to how to do so, I would suppose his life expectancy should be at least 85. So he has around a 50/50 chance of reaching 2060, given only current projections. With all the money and research being put into anti-aging, of which his efforts are a part, I would say it's quite pessimistic to state he wont live to see aging defeated by 2060.

Kudos for realizing some of the often missed implications of rejuvenation, like "till death do us part" -type marriages having an entirely different meaning with eternal youth.

But I think you could skip a few years of constant thinking and deliberating by just reading this book: https://www.amazon.com/dp/B06XP5Z3W4

It literally takes us from todays society through every issue we are faced with now and until the very end of the universe, and then some. Without needing things that for various reasons simply won't happen (like massive national space agency projects for space settlement, or global cooperation to deal with climate change).

I have to point out that it is my book, I would link to another book if there actually existed a second such book. I wouldn't even have bothered to write this one if there was a book like it already. But I got so annoyed by all the fantasies about generation ships and floating space farms, when some Finns are converting air and electricity into proteins https://solarfoods.fi/ and aging simply won't exist by the time anyone can set sail to another solar system thanks to http://www.sens.org/ and others who follow their strategy. So I just had to write it, because every single piece of science fiction and future-oriented non-fiction was completely and utterly unaware of things such as this.

Yes, I believe it is. As far as I know, all the present 'NAD precursors' have limited bio-availability and most longevity insiders don't believe they will do anything much. Jim Mellon, the author of Juvenescence, recommends we wait for David Sinclair's own product to come out, which is indeed supposed to be bio-available. Not sure what if any links he (Jim Mellor) might have to Sinclair.

​

There is one NAD supplement that Jim Mellor admits to taking daily, although he doubts its effectiveness. 'Basis' by Elysium, is backed by a number of Harvard professors (including George Church). It's supposed also to be more bio-available than most NAD precursors.

https://www.elysiumhealth.com/en-us/basis

​

https://www.amazon.com/Juvenescence-Investing-longevity-Mellon-Jim/dp/0993047815/

​

The good news is that there are actually multiple, up-to-date textbooks on the biology of aging:

• Biology of Aging (2nd Edition) - Roger B. McDonald (Published 2019)
  
• Biology of Longevity and Aging: Pathways and Prospects - Robert Arking (Published 2019)
  
• Human Biological Aging: From Macromolecules to Organ Systems - Glenda E. Bilder (Published 2016)
  
  Caleb Finch also wrote a textbook, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans, but it was published in 2007 and hasn't been updated since. There's also the 8th Edition of the Handbook of the Biology of Aging, published in 2015.