Reddit mentions of 3M Wireless Ergonomic Optical Mouse, Patented Vertical Grip Design Keeps Your Hand and Wrist at a Neutral Angle for Comfort, USB Plug and Play, Soft-Touch Surface, Large Size, Black (EM550GPL)

I have to say my hands feel uncomfortable just reading this. I remember moments when the smallest movements would feel like they are about to break my hands. I hope you are seeing progress though.

Is it the aiming or pressing the buttons that aggravates your condition? I used to switch my hand and used left hand one day and right hand another day. I also used a mouse that is vertical (and it sucks to use it but at the time it was perfectly helping).

This is the mouse: https://www.amazon.co.uk/3M-EM550GPL-Optical-Ergonomic-Wireless/dp/B001H9UGD4/

I further used application to avoid using mouse in general. I have basically the whole linux environment that allows me to rarely use mouse.

For example, in the case of a browser, I use a vim plugin. This means that I can press hyper-links without using my mouse.

I also remember in one review that stress is a factor. I can't tell you what helped exactly, because I have reoriented my life around it, and tried to many things. Was it the tread mill I had? Was it the sport I did all the time?

I am at the point where I am also more happy and slightly less stressed. And that apparently is a factor too. Stress in general - which incrases inflammation - which is the "source" of the issue in hands. I am also taking a bit of aspirin and ibuprofen pills (and occasionally use the topical cream). They are anti-inflammatory which means they might be addressing the source of the issue. Prolonged inflammation affects negatively the cellular environment.

I also have the powerball now (two months) and I should try it more. But I am more hopeful about the back-stretching.

Try moving the receiver around to better locations. Also, if you are using rechargeable batteries, the signal is going to be weaker (rechargeable batteries are 1.2V, rather than 1.5V).

Maybe he could try this one (Amazon.com)

If he works well with the joystick on his chair, perhaps a wireless joystick attached to his chair would work. This one (Amazon.com) looks promising. You can also find some others (Amazon.com)

Do any of these look like they could work? If not, we can concentrate on your current mouse, but I think there's quite a few large hurdles in that effort.

I don't like trackballs, but I wish there was more effort put into mice like these: 1 and 2.

Having your hand flat on a mouse (or trackball) is not very ergonomic.