(Part 2) Best products from r/longevity

Michael Lustgarten is the author of 'Microbial Burden'.

Profile on Leafscience.org: https://www.leafscience.org/dr-michael-lustgarten-using-an-evidence-based-approach-for-optimal-health-and-longevity/

In the video he goes over some of his educational background, experience with researching associations between gut bacteria and health. Currently the field is immature and we don't know, maybe in the future there will be individual recommendations for ways to alter the microbiome for better health - currently there is a gap. He thinks a high fibre diet (>65g of fibre) is likely beneficial for improving gut barrier function and keeping things out of the blood that should only be in the gut.


He says he does regular blood testing while making changes to his diet to self experiment around biomarkers of aging, based on CBC blood panel which costs him $30 a pop. He inputs the results of this standard blood test into the aging.ai website, a deep-learned predictor of your age made with a deep neural network trained on hundreds of thousands anonymized human blood tests, built by insilico medicine. He suggests anyone can do this too.

Epigenetic age, he thinks may be more reliable (predictive of health), but is currently cost prohibitive ($300 per test) for regular testing based on his income.

Concluding stuff: he hopes that all the bright minds will converge on figuring out aging as he'd like to live healthy for a long time.

For those who didn't see the previous post and discussion: https://www.reddit.com/r/longevity/comments/4r3418/the_first_step_towards_escape_velocity_and_why_de/

While I am still skeptical, I'm interested in hearing about your mouse studies and your own self-experimentation. I hope you keep us updated in the future. By the way, what are you limiting your calcium intake to?

As I read your post, one thing that came to my mind was the book [The Blue Zones] (https://www.amazon.com/Blue-Zones-Second-Lessons-Longest/dp/1426209487/ref=sr_1_1?ie=UTF8&qid=1467840484&sr=8-1&keywords=Blue+Zones). If you don't know, Blue Zones are areas of the world where people are much more likely to live to 100. One Blue Zone is Nicoya, Costa Rica where the locals drink very hard water that contains high levels of calcium and magnesium. Perhaps these centenarians are just better at handling high amounts of calcium, but the book also referenced a 2004 World Health Organization paper that found that populations with hard water had 25% fewer deaths from heart disease, since calcium is essential for muscle contraction (The Blue Zones; pg. 202). I suppose the results could be due to other minerals in the water that outweigh the ill effects of calcium, but nevertheless I thought you should be aware of this. I know you mentioned that the Japanese consume much less calcium than Westerners, perhaps you should research the average calcium intake of other long lived populations. Maybe that would show that Nicoyans are an outlier in their calcium intake.

> fermented foods

Fermented foods are overhyped and should not be the "go to" source of "probiotics". See: /r/HumanMicrobiome/comments/6k5h9d/guide_to_probiotics

Beyond the things you listed there is Fecal Microbiota Transplants (FMT) from someone young and in perfect health.

You can also see that link for info on phages. I take this one: https://www.amazon.com/gp/product/B01CTCATS4/

Check out this book. The title and marketing campaign are a little hokey but it's chock full of research-backed ruminations on proper exercise and its health benefits. The chapter on global metabolic conditioning might break you out of the aerobic vs. anaerobic paradigm; they're not diametrically opposed but instead necessarily complement each other in any muscular contraction.

You can ask Aubrey de Grey aubrey@sens.org , hovewer, would you like to work in molecular nanotechnology? Make CAD program for designing nanomachines for medicine?

https://www.amazon.com/Nanomedical-Device-Systems-Design-Possibilities/dp/0849374987

I recently started taking NAD+ Cell Regenerator (Nicotinamide Riboside) from LifeExtension : https://www.amazon.co.uk/Life-Extension-Regenerator-Nicotinamide-Riboside-x/dp/B00NPXDXNA/

Do you think this supplement would have any benefit at all? (It's quite expensive).

Basis is overpriced

Just get

https://www.amazon.com/gp/product/B01NA93UAK/ref=oh_aui_detailpage_o05_s00?ie=UTF8&th=1

and

https://www.amazon.com/Absorb-Health-Pterostilbene-Capsules-Count/dp/B00JQS5T76

same thing as basis, MUCH cheaper.

youre welcome

A couple of years ago, in a talk, Aubrey waved two big books when the topic came up about how to get started. The books were:

• Essential Cell Biology
  
• Molecular Biology of the Cell
  
  (and SENS would most likely also recommend keeping Ending Aging handy).

Here's a link. It's 333 mg.


https://www.amazon.com/NAD-Ignite-NIAGEN-Nicotinamide-ProHealth/dp/B071Z74GJ4/ref=sr_1_8?ie=UTF8&qid=1504274903&sr=8-8-spons&keywords=prohealth+niagen&psc=1

Here's a discussion I just found about it that you might be interested in. http://www.longecity.org/forum/topic/73837-nicotinamide-riboside-nrniagen-vendor-vetting-and-discussion/

The addressable ones are a lot of fun to work with - I got 200 of the individual module ones and it's my goto when I need a to add a light to anything now. I have a strip of 5050's sitting around because of it - if you only need a handful of them, you can power it all with 3 wires connected directly to the arduino (after a certain number it'll draw too much power to run through the board).

​

As far as the clock, I've never needed one before. I usually would use something like a raspberry pi zero (I have extras lying around) or the ESP8266 and keep the clock synced over wifi. They can be more complicated to work with though...the raspberry pi doesn't always come back after losing power, and the ESP8266 (like a little arduino with built in wireless) is more finicky than the mainstream arduinos,

​

Any real time clock module should be fine, this is the one I would buy at this moment because it has it's own battery which would be helpful if you lose power, but you can buy a pack of other ones for not much more.

​

Any RTC module should be more than sufficient for your needs - even the cheapest quartz clock will keep the drift to a fraction of a second per day

The good news is that there are actually multiple, up-to-date textbooks on the biology of aging:

• Biology of Aging (2nd Edition) - Roger B. McDonald (Published 2019)
  
• Biology of Longevity and Aging: Pathways and Prospects - Robert Arking (Published 2019)
  
• Human Biological Aging: From Macromolecules to Organ Systems - Glenda E. Bilder (Published 2016)
  
  Caleb Finch also wrote a textbook, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans, but it was published in 2007 and hasn't been updated since. There's also the 8th Edition of the Handbook of the Biology of Aging, published in 2015.

I took it for a couple weeks and it gave me some mild side effects, possibly because I was taking it in a fasted state. Side effects: a little too much energy and some anxiety. I'm going to start taking it again, but this time with my meal. (I do OMAD)

What I was using: https://www.amazon.com/gp/product/B00NPXDXNA/ref=ox_sc_act_title_2?smid=A1H4J1GB42KZ6X&psc=1

anyone tested this one?
https://www.amazon.co.uk/dp/B07TC7M13T/ref=cm_sw_em_r_mt_dp_U_GNhKDbP0DNGPD

I saw that his new book comes out in a few months: https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/1501191977

https://www.amazon.com/Relaxation-Response-Herbert-Benson/dp/0380006766

Ending Aging

This, ladies and gentlemen, is the main reason aging happens
and it is already relatively easy to fix: Identify the microbes in question and kill them.

The author has also written a book:
https://www.amazon.com/Microbial-Burden-Major-Age-Related-Disease-ebook/dp/B01G48A88A/ref=sr_1_8?s=digital-text&ie=UTF8&qid=1526332350&sr=1-8&keywords=lustgarten