Reddit mentions of Alzheimer's Solved: Condensed Edition

I came across this book when I Google'd a hypothesis I had that since my own father went on antistatins and developed dementia not long after ,and because the brain needs cholesterol, that depriving the brain of cholesterol might be related to Alzheimer's.

In the search results this book came up amid hundreds of "professional" pro statin posts about studies funded by statin drug makers that say statins might "help" those with Alzheimer. (the statin drug makers made 10 BILLION dollars in 2004 so they have money to stuff the internet and thus search results with referenced glory reports)

Well anyone who has had experience with the statin studies knows how suspect and blatantly corrupt so many have proven to be in the past, and frankly starving the body of essential fatty acids like cholesterol would logically affects organs like the brain that are largely composed of fatty acids and lipids so i looked on down to the later search results pages.

this article came up
http://www.spacedoc.com/alzheimers_statins.htm
which mentioned this book Alzheimer's Solved", by Henry Lorin

I quote that article"

"A new book, "Alzheimer's Solved", by Henry Lorin is a "must read" for every student of this subject.
Lorin states that in the majority of cases Alzheimer's disease is caused by long-term shortages of cholesterol in the elderly brain. He finds only two exceptions to this rule: Down's syndrome and those with a history of brain injury or surgery."
His interest in the subject of the relationship began nearly ten years ago with his observation of the very low incidence of Alzheimer's disease in type-2 diabetes. He noted that as a general rule this form of diabetes is associated with obesity and high blood cholesterol levels. He found that Cree Indians with their genetically predisposed diabetes of this type and high cholesterols have very low likelihood of Alzheimer's disease. He wondered could a high blood level of cholesterol offer some protective effect against the development of Alzheimer's disease? He lists an impressive 2500 references in his decade of study.

Lorin's book carries the reader from cholesterol's role in brain structure and function to the process of subtle semi-starvation in the elderly with secondary low serum cholesterol levels and elevated cortisol levels reflecting low-grade stress. From this he takes the reader to a compelling case for amyloid deposition as a substitute for insufficient cholesterol, neuronal degeneration, brain shrinkage and the progressive evolution of Alzheimer's disease.

It is a fascinating read based on known observations, for most cases of this dread disease are malnourished with low serum cholesterol and high serum cortisols. The body is under stress. Cholesterol manufacture and replacement is compromised. Amyloid is Mother Nature's band-aid according to this author, a poor substitute for cholesterol in the lay-down of myelin and in synaptic formation and function, leading to impaired neuronal function and death.

I have reported in another page the astounding findings of Muldoon that 100% cognitive impairment is demonstrable in statin users if a sufficiently sensitive test battery is used. These complaints range from transient global amnesia, to aggravation of pre-existing senility to forgetfulness, disorientation and confusion. The mechanism of this side effect is clearly rooted in the biosynthesis of cholesterol and likely is relevant to Lorin's observations about the predisposition to Alzheimer's disease of those with low serum cholesterol.

Only in the past several years have we learned the importance of cholesterol in brain function. Cholesterol has now been proven to be absolutely vital in the formation and function of the trillions of synapses in our brains. Now Lorin suggests that diminished bio-availability of cholesterol may be the key to Alzheimer's disease. It certainly fits the data of both Muldoon and Pfrieger."


on the web page for the book a reviewer (who i assume is independent but makes logical sense in any case) says


"Ordinarily the demand for cholesterol is high but under certain conditions demand exceeds supply introducing the second major actor in this Alzheimer's play, amyloid. All cells have a ready supply of amyloid in the form of amyloid prescursor protein. When cholesterol is needed but cannot be supplied it is this amyloid that becomes an emergency, temporary filler.

Amyloid then is purely an emergency patch job when cell membranes need repair under conditions of insufficient cholesterol. Incidentally, cholesterol is usually carried about in LDL form while amyloid is carried about primarily in platelets. Lorin now begins to weave these major players together with impressive skill to produce a very compelling view of the Alzheimer's process. Certainly his story is extraordinary and yet it fits better than anything else I have read on the subject. "

"Also relevant to a full understanding of this book is the fact that the Alzheimer's victim in this book was his beloved father-in-law, who also had been placed on statin drugs before his first signs of Alzheimers disease because of coronary artery blockage. His initial cholesterol levels in the mid three hundreds were brought down to just under two hundred by the use of statins and diet.

Alzheimers disease began in his father-in-law in1990, nine years before death. Prior to writing this book Dr. Lorin reviewed thousands of references taking a remarkable 77 pages in his book just to list them. That in itself is an incredible task of the type usually required only for major review articles. "