Reddit mentions of The New Mind-Body Science of Depression

They did, however, that was a year and a half ago with no updates since, and it seemed more like a business move rather than anything else IMO. NSI failed to reach statistical significance in the primary endpoint, namely the clinician-rated scale MADRS. Earlier this year they also announced that they're expanding their pipeline. By all accounts, though they haven't explicitly stated so, it seems clear to me that they're not pushing it forward for MDD.

It's an interesting case, I was really hoping NSI would succeed as it seemed to have the potential to do, the self-rated scales don't lie, people actually felt better and stayed better until the last follow-up. Neuralstem made a good point about the MADRS and HAMD scale being 4-decade old scales designed primarily with tricyclics in mind, and they also do not capture atypical symptoms of MDD. It does seem a bit silly testing such a novel drug with ancient scales, and perhaps it would have succeeded otherwise.

I took it for about 2 weeks and it gave me severe neuropathic pain in my foot. I was almost limping around for a few days. You made a good point about these shady Chinese sources. On the other hand, most of the synthetic nootropics people are taking are synthesized in China.

I'm going into my 4th year of a Pharmacology degree, and I have been seriously thinking about going into mental health, precisely due to the reasons you stated. It's clear that our current understanding of depression is lackluster, and our treatments are really poor. I think there's so much potential for discovery and improvement in this field, and the movement has already started with the likes of esketamine, and the large number of new compounds currently in clinical trials (the article that I linked in my previous reply), many of which work through novel mechanisms.

Check out the highly influential study by Irving Kirsch in 2008: https://www.ncbi.nlm.nih.gov/pubmed/18303940/

This book is on my list as it seems to be a very comprehensive resource: https://www.amazon.com/New-Mind-Body-Science-Depression/dp/0393706664

Revitalising monoamine oxidase inhibitors: https://www.cambridge.org/core/journals/cns-spectrums/article/revitalizing-monoamine-oxidase-inhibitors-a-call-for-action/32497C0FE4F08D0D4C07E6350A91B0EE