Reddit mentions of Jestik HE Ergonomic Vertical Mouse, Large, Right Handed, Wired, 500-3500 DPI

I'm just not sure there needs to be a "next level" here.

There are a few distinct variations on the mouse. For example, the 3D mouse, Apple's Magic Mouse, or perhaps a variation on the ergonomic mouse, and let's not forget the trackball mouse.

But, lots of people have tried to make a "next level" mouse without anything really catching on. Also consider how many programs have hotkeys that don't involve a mouse. Lots of power users on all types of systems (definitely including Windows) avoid touching the mouse if they don't have to, as it adds up as wasted time throughout the day.

Instead of trying to design something that everyone else would use, let's start trying to find the problem that you appear to be trying to solve. And to do that, let's start with your day-to-day. What actions do you perform in your normal day-to-day that you feel like would make more sense to move to the mouse? Do you already use an "MMO Mouse" with 20 buttons? If not, this might be the way forward for you.

I find that most people who still use a mouse are either in a workplace environment or they are playing computer games. Note that lots of people casually browsing the internet at home (not playing PC games, and not actively working) aren't even using a mouse at all.

No idea about the mouse/trackball combo but curious about the "vertical mouse surface". Why? What's the benefit? That way you have to constantly hold the weight of your arm and the mouse and isn't that awkward to use?
I would rather use a vertical mouse, something like that. Vertical hand position without the (to me seemingly negative) effects of a vertical surface.