Reddit mentions: The best industrial & technical chemistry books

>But the first doesn't logically follow from the second.

In my limited experience (undergraduate classes in drug development in a BS in Biology, and Drug Development textbooks), it does follow. The cost of generating new pharmaceuticals is ridiculous. My Intro to Drug Development text claims modern averages of $1 billion dollars and 7-12 years to whittle an average of 10,000 drug candidates down into 1 FDA approved drug. The question isn't the country that the company resides in, but rather the wealth of the affected population. Can the people who need your drug afford a cost that recoups your investment? For orphan diseases (US Law defines orphan disease as affecting fewer than 200,000 people total) and tropical diseases, the group of affected people who can also afford the cost of the treatment isn't generally big enough to recoup cost. (10,000 treatments at $10,000/pop is $100,000,000 revenue, or 1/10 the average cost of development. So 100,000 treatments at $10,000/pop 'recoups' the $1billion dollar investment with zero profit, using very generalized and thus inaccurate numbers. Do we think that the people of Uganda or Guinea can afford 100,000 separate $10,000 treatments of a drug that could be technically produced at-cost for $10/pop?)

Text in question: http://www.amazon.com/Drugs-Discovery-Approval-Rick-Ng/dp/047019510X Amazon has the ability to read the first chapter, and Chapter 1 Page 5 is where my information (besides my back of envelope math) above comes from. All of Chapter 1 will provide a great high-view of the FDA and the drug development process.

Another source from 2001: http://www.medscape.com/viewarticle/405869_4

Considering a 10 year, 1 billion dollar price tag, the profitability question quickly drops for tropical and orphan diseases. This is why the US government and other Western Governments devote a lot of money in the form of incentives for companies to engage in long-term traditionally unprofitable research.

>some entrepreneurial pharmacologist could start one, and then make a ton of money by being the only vendor of tropical medications. (Or, an existing company could send researchers to the tropics and develop its own drugs, until the tropical market was no longer underserved.)

This falls under the assumption "meeting the markets needs can be profitable" but no pharmaceutical company has, to my knowledge, found a way to cure orphan and tropical diseases with profitability. Remember, tropical diseases ravage places that cannot afford the $1000 treatment (or 10,000, or 100,000. Depends on the orphan or tropical disease and how many people it affects), and call it human rights crimes when the drug is not sold at manufacturing cost (typically several orders of magnitude lower than the full cost of discovery and pre-trialing the other 9,999 average failed drug candidates per 1 approved drug). This is a dilemma: it is "immoral" to sell drugs at a cost that recoups investment (and cannot be afforded by the peoples of tropical nations), or impossible to profit from investing in new drugs while selling said drugs at cost.

This isn't my topic of expertise, so I don't want to run afoul of rules, but ideas like the Health Impact Fund (http://en.wikipedia.org/wiki/Health_Impact_Fund) are designed to introduce profit incentives to orphan and tropical diseases so that this very problem can be solved using the current market infrastructure. Such plans would be unnecessary if tropical diseases could be cured profitably as is.

As a pure reference encyclopedia Rang and Dales pharmacology is an excellent resource. All information is presented clearly and has brilliant diagrams and tables which explains concepts well. It is a little large and heavy to carry around though.

I am currently reading Toxicology: Principles and Methods by M A Subramanian and I find it very well presented and concise, also fits in a bag easily and isn't too heavy so is practical to carry around.

For pleasure:

• The Disappearing Spoon
  
• Periodic Tales
  
• Stuff Matters
  
• Molecules of Murder
  
• The Elements of Murder
  
• The Elements
  
• Molecules
  
• Molecules that Changed the World
  
• The Chemistry Book
  
  Undergraduate
  
  
• Organic:
  Organic Chemistry as a Second Language, The art of writing reasonable organic reaction mechanisms
  
  
• Inorganic: Inorganic Chemistry, Molecular Symmetry and Group Theory
  
  
• Analytical: Principles of Instrumental Anlsysis, Fundamentals of Analytical Chemistry
  
  Graduate
  
  
• Organic: Advanced Practical Organic Chemistry, March's Advanced Organic Chemistry, Greene's Protective Groups in Organic Synthesis, Purification of Laboratory Chemicals, Strategic Applications of Named Reactions in Organic Synthesis
  
• Inorganic: Advanced Inorganic Chemistry

For a fun recreational textbook, and if you think nuclear explosions are cool, take a look at Physics of the Manhattan Project geared towards college students who have completed a few upper division courses.

If anyone wants the science on this topic, a book was finally written by a professor of pharmacology at the U of Arizona.
https://www.amazon.com/Most-Misunderstood-Molecule-4-Dinitrophenol-Pharmacology/dp/1985234661/ref=sr_1_2?ie=UTF8&qid=1522800925&sr=8-2&keywords=schnellmann (Amazon book: Schnellmann is author)
She knows her &^it. Get all the info here before trying this out. I got the book. It is the best and most complete resource available. It is the only science-based resource in existence.

See if you can't buy/check out the REA Chemistry CLEP book for a refresher. I bought the three books for my three exams, read through each and took the two included practice exams, and passed all three of my CLEPs on the first go with just two days studying for each. Had been more than 10 years since I had taken a history class (and I never even took Psych!). Easier subjects than chem though, of course.

That's because you didn't link the current editions... here those are:

$135.45 https://www.amazon.com/Elements-Chemical-Reaction-Engineering-International/dp/0133887510

$201.77 https://www.amazon.com/Physical-Chemistry-Thermodynamics-Structure-Change/dp/1429290196

$121.53 https://www.amazon.com/Separation-Process-Principles-Applications-Simulators/dp/1119355230

$210.63 https://www.amazon.com/Chemistry-Steven-S-Zumdahl/dp/1305957407

Sub-Total $669.38 + $53.55 Tax = $722.93 Grand Total

See if your library has access to a book on protective groups or can request a copy from another university. This may be a good starting point: https://www.amazon.com/Greenes-Protective-Groups-Organic-Synthesis-ebook/dp/B00MNBZRVG/ref=sr_1_1?ie=UTF8&qid=1540047245&sr=8-1&keywords=Organic+protecting+groups

The CRC Handbook of Chemistry and Physics

Elements of Chemical Reaction Engineering, $135 new

Physical Chemistry, 9th edition (newer), $74 used (out of print)

Separation Process Principles, $121 new

I have a hard time believing that basic Chemistry book is $670

edit: someone beat me to it, the chemistry book is not $670, its $50

The wiki was the fucking reference that shows the textbook reference

You are being an unreasonable, close-minded asshole.

UPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook.

http://www.amazon.com/Physical-Chemistry-David-W-Ball/dp/1133958435/ref=sr_1_2?ie=UTF8&qid=1398351704&sr=8-2&keywords=Physical+Chemistry%2C+textbook+by+David+W.+Ball%3A+Chemistry%2C+Physical+chemistry (Search inside this book for Eyring)

http://www.amazon.com/Computational-Chemistry-Introduction-Applications-Molecular/dp/9048138612/ref=sr_ob_1?s=books&ie=UTF8&qid=1398351980&sr=1-1 (Search inside for Eyring)

http://www.academia.edu/3600599/The_many_footprints_of_Henry_Eyring Not a book, but a good read

He also wrote textbooks himself, but I don't care to do the work to look them up for someone who asks for one textbook reference and then mocks the source of where I found that textbook.

Fuck you.